About AADB

AADB was developed as a curated gene/protein-level resource for microbial pH stress adaptation, with a focus on mechanism-oriented organization and sequence-based usability.

Project Purpose

AADB was designed to support the study of microbial acid and alkaline resistance by organizing curated pH-related genes and proteins into interpretable functional systems.

Data Sources

AADB integrates curated pH-resistance-related protein entries and associated annotations derived from public sequence resources and structured curation workflows.

Processing Workflow

The AADB release workflow includes candidate retrieval, sequence cleaning, deduplication, metadata normalization, and release alignment across FASTA, table, and machine-readable outputs.

Implementation

The current web application is implemented in Flask and provides interactive browsing, BLAST search, statistics visualization, and downloadable database outputs.

Maintenance and Contact

AADB is an actively maintained academic resource. Future releases will expand sequence coverage, improve evidence transparency, and further enhance sequence-centered annotation workflows.

Citation

If you use AADB in your research, please cite:

AADB: Acid/Alkaline Resistance Gene Database. A curated database of microbial genes and functional systems conferring resistance to acidic and alkaline environments. Version 1.2. Available at: https://github.com/Thresh514/AAdb